Ambroxol hydrochloride( NA 872 | Abrohexal | Ambril | Ambro-Puren Ambrobeta | Duramucal | Ebromin | Mucosolvan )

Catalog No. M13688 CAS No. 23828-92-4

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Product Name

Ambroxol hydrochloride
Note

Research use only, not for human use.
Brief Description

Ambroxol HCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block.
Description

Ambroxol HCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
In Vitro

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In Vivo

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Synonyms

NA 872 | Abrohexal | Ambril | Ambro-Puren Ambrobeta | Duramucal | Ebromin | Mucosolvan
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel
Research Area

Neurological Disease
Indication

——

CAS Number

23828-92-4
Formula Weight

414.56
Molecular Formula

C13H18Br2N2O·HCl
Purity

>98% (HPLC)
Solubility

DMSO: 3 mg/mL (7.23 mM)
SMILES

OC1CCC(N(C2=CC(Br)=CC(Br)=C2N)C)CC1.[H]Cl
Chemical Name

4-((2-amino-3,5-dibromophenyl)(methyl)amino)cyclohexan-1-ol hydrochloride

1.Weiser T, et al. Mol Pharmacol, 2002, 62(3), 433-438.

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